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Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32)

Authors
  • Brestovac, Brian
  • Halicki, Larissa A.
  • Harris, Ryan P.
  • Sampson, Ian
  • Speers, David J.
  • Mamotte, Cyril
  • Williams, David1, 2, 3, 4, 5, 6, 7, 8, 9
  • 1 School of Biomedical Sciences
  • 2 CHIRI Biosciences Research Precinct
  • 3 Faculty of Health Sciences
  • 4 Curtin University
  • 5 Department of Microbiology
  • 6 Pathwest Laboratory Medicine WA
  • 7 Queen Elizabeth II Medical Centre
  • 8 School of Medicine and Pharmacology
  • 9 University of Western Australia
Type
Published Article
Journal
Microbes and Infection
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Feb 21, 2014
Identifiers
DOI: 10.1016/j.micinf.2014.02.007
Source
Elsevier
Keywords
License
Unknown

Abstract

Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35–2.1).

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