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PriA is essential for viability of the Escherichia coli topoisomerase IV parE10(Ts) mutant.

Authors
Type
Published Article
Journal
Journal of bacteriology
Publication Date
Volume
186
Issue
4
Pages
1197–1199
Identifiers
PMID: 14762016
Source
Medline
License
Unknown

Abstract

The parE10(Ts) mutation, which renders Escherichia coli thermosensitive for growth by inactivation of the essential E. coli topoisomerase topo IV, is lethal at all temperatures when PriA, the main replication restart protein, is absent. This lethality is suppressed by the activation of a PriA-independent replication restart pathway (dnaC809 mutation). This result suggests that topo IV acts prior to full-chromosome replication completion.

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