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Preventive Effect of Saussurea lappa Extract on Osteoarthritis in Mice Model through Inhibition of NF-κB Pathway

Authors
  • Feng, Dong1
  • Zhu, Xiaohu2
  • 1 Department of Orthopaedics, First People’s Hospital of Tancheng County, Linyi, Shandong Province, 276100, China , Linyi (China)
  • 2 Department of Orthopedics, Funing County People’s Hospital, Funing County, Yancheng, Jiangsu Province, 224400, China , Yancheng (China)
Type
Published Article
Journal
Doklady Biochemistry and Biophysics
Publisher
Pleiades Publishing
Publication Date
Mar 10, 2021
Volume
496
Issue
1
Pages
56–61
Identifiers
DOI: 10.1134/S1607672921010142
Source
Springer Nature
Keywords
License
Yellow

Abstract

AbstractThe current study evaluated Saussurea lappa extract (SLE) as possible therapeutic agent for osteoarthritis treatment in mice model. Male BALB/c nude mice were separated into sham, model and SLE treatment (at 1.0, 1.5, 2.0, 2.5, and 3.0 mg/kg) groups. Osteoarthritis mice model was prepared by injecting 5 mg/kg doses of monosodium iodoacetate (MIA) to mice via intra-articular route. The SLE was injected to mice for 20 days from day 2 of MIA injection through intraperitoneal route. The SLE treatment alleviated OA-induced higher secretion of interleukin-6, TNF-α, and IL-1β in mice serum. Moreover, elevated levels of P2X7R and MMP-13 in OA mice were also significantly down-regulated on treatment with SLE. In OA mice SLE treatment suppressed expression of SP and PGE2 in cartilage tissues. The expression of activated IκBα and NF-κB p65 was also inhibited markedly by SLE treatment in OA mice. In summary, SLE has protective effect on osteoarthritis in mice by targeting interleukin overproduction and P2X7R expression. Besides, it suppressed MMP expression and deactivated NF-κB signaling pathway. Therefore, SLE can be developed for the treatment of osteoarthritis.

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