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Prevention of recurrent episodes of rhabdomyolysis with tacrolimus in a transplant recipient with myopathy.

Authors
  • Sathyan, Sharad
  • Baskharoun, Rawya
  • Perlman, Alan S
Type
Published Article
Journal
American journal of therapeutics
Publication Date
Jan 01, 2014
Volume
21
Issue
5
Identifiers
DOI: 10.1097/MJT.0b013e318274df46
PMID: 23429166
Source
Medline
License
Unknown

Abstract

Genetic muscular disorders are known risk factors for rhabdomyolysis, which may result in acute kidney injury. Recurrent episodes of acute kidney injury can lead to chronic kidney disease and eventually end-stage renal failure. We describe a patient with chronic kidney disease that developed in the setting of recurrent rhabdomyolysis, resulting in the requirement for renal transplantation. After transplantation, the maintenance of tacrolimus trough concentrations above what is typically prescribed for standard renal transplant recipients appeared to confer protection from further episodes of rhabdomyolysis. This is consistent with previous case series that demonstrated a therapeutic benefit of the calcineurin inhibitor cyclosporine in collagen VI myopathies in the nontransplant population. This case report suggests the potential application of higher tacrolimus targets in patients who have undergone renal transplantation in the setting of recurrent rhabdomyolysis leading to end-stage renal failure.

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