External abdominal hernia is a common clinical disease. The application of hernia patch is a breakthrough in the treatment of external abdominal hernia. However, complications such as patch infection need to be solved urgently. Patch infection markedly prolongs the hospitalization time and increases the medical expenses of patients. At present, a standard method for the diagnosis, treatment, and prevention of patch infection remains to be developed. This paper summarizes the literature in recent years to explore the research progress in the prevention and treatment of patch infection.