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[Prevention of ischemic damage to the liver monooxygenase system with lidocaine and alpha-tocopherol].

Authors
  • Grek, O R
  • Sharapov, V I
Type
Published Article
Journal
Farmakologiia i toksikologiia
Publication Date
Jan 01, 1987
Volume
50
Issue
5
Pages
60–64
Identifiers
PMID: 3691783
Source
Medline
License
Unknown

Abstract

In experiments on rats it was shown that the liver ischemia produces a decrease of the maximal rate of amidopyrine and aniline hydroxylation in microsomes on the 3rd day of the postischemic period. A considerable depth of aniline metabolism inhibition following hepatic ischemia is related to reduced affinity of cytochrome P-450 to substrates of type II. On the 3rd and 14th days of the postischemic period the Michaelis constant and the constant of spectral dissociation for aniline significantly exceeded the given kinetic parameters in control animals. Administration of alpha-tocopherol in combination with lidocaine prevented a decrease of the rate of amidopyrine N-demethylation, the concentrations of cytochromes P-450, b5 and prevented a reduction of cytochrome P-450 affinity to aniline.

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