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[Prevention of heart damage of sodium oxybutyrate in terminal states caused by acute blood loss].

Authors
  • Meerson, F Z
  • Dolgikh, V T
Type
Published Article
Journal
Kardiologiia
Publication Date
Oct 01, 1982
Volume
22
Issue
10
Pages
38–44
Identifiers
PMID: 7176316
Source
Medline
License
Unknown

Abstract

After clinical death caused by acute blood loss, hearts of rats were essentially damaged. In isolated hearts, these damages were manifested in the decrease of major contractility parameters with the preferential disturbance of relaxation, increased loss of enzymes (lactate dehydrogenase and creatine phosphokinase) into the perfusate and a significant decrease of the cardiac muscle resistance to hypoxia. All these effects could be, to a large extent, prevented by gamma-hydroxybutyric acid, an endogenous metabolite having central inhibitory effect, which was administered to the animals before the loss of blood.

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