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Prevention of alcohol withdrawal seizures with phenytoin in rats.

Authors
  • Chu, N S
Type
Published Article
Journal
Epilepsia
Publication Date
Apr 01, 1981
Volume
22
Issue
2
Pages
179–184
Identifiers
PMID: 7193576
Source
Medline
License
Unknown

Abstract

The efficacy of phenytoin in the prevention of alcohol withdrawal seizures was studied in rats. Phenytoin was administrated together with and again 12 hr after the last dose of chronic alcohol feeding. Protection against alcohol withdrawal seizures was not observed when phenytoin serum levels were below 8 micrograms/ml. However, with phenytoin serum levels between 8-25 micrograms/ml, only 1 out of 32 rats had alcohol withdrawal seizures.

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