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Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation

Authors
  • Festag, Julia1
  • Thelemann, Tamara1
  • Schell, Monika1
  • Raith, Stefanie1
  • Michel, Sven1
  • Jaschinski, Frank1
  • Klar, Richard1
  • 1 Secarna Pharmaceuticals GmbH & Co. KG, 82152 Planegg/Martinsried, Germany
Type
Published Article
Journal
Molecular Therapy — Nucleic Acids
Publisher
Elsevier
Publication Date
Jun 27, 2020
Volume
21
Pages
656–669
Identifiers
DOI: 10.1016/j.omtn.2020.06.020
PMID: 32739778
PMCID: PMC7393471
Source
PubMed Central
Keywords
License
Unknown

Abstract

The unleashing of antitumor immune responses by targeting the purine metabolism has emerged as a promising strategy in cancer immunotherapy. Festag and colleagues targeted different components of the purine metabolism using antisense oligonucleotides and small molecules and could show that T cell proliferation and cytokine release are differentially suppressed by distinct purine metabolites.

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