Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation
- Authors
- Type
- Published Article
- Journal
- Molecular Therapy — Nucleic Acids
- Publisher
- Elsevier
- Publication Date
- Jun 27, 2020
- Volume
- 21
- Pages
- 656–669
- Identifiers
- DOI: 10.1016/j.omtn.2020.06.020
- PMID: 32739778
- PMCID: PMC7393471
- Source
- PubMed Central
- Keywords
- License
- Unknown
Abstract
The unleashing of antitumor immune responses by targeting the purine metabolism has emerged as a promising strategy in cancer immunotherapy. Festag and colleagues targeted different components of the purine metabolism using antisense oligonucleotides and small molecules and could show that T cell proliferation and cytokine release are differentially suppressed by distinct purine metabolites.
