Tuberculosis (TB) is one of the major prevalent disease, which is caused by Mycobacterium tuberculosis and among all the diseases it exists in harmful condition. The long term cough with blood sputum and fever is the major symptom of tuberculosis. In 2014, 1.5 million TB patients were dead from the 9.6 million active TB patients. Every second someone in the world affected by M. tuberculosis and 10% of the affected people will be infected in their later period of life. The global scenario in terms of TB infection is varies from one country to another. Developing country like Bangladesh stands on much more harmful condition. According to WHO Global TB Report 2016, Bangladesh is one of the world's 30 high TB burden countries and near about 73, 000 people die annually due to Tuberculosis. In addition, Multi Drug Resistance Tuberculosis (MDR-TB) is increasingly affected the people and it is now a major concern for disease prevention. The infection chances of a HIV affected people are much higher than a healthy people in case of tuberculosis. Although, the infection rate of tuberculosis is increasing over the last few decades, but new anti-Tb drugs show greater audacity to eradicate critical situation of tuberculosis. Through the molecular analysis, researchers pointed out the M. tuberculosis resistance, which will give us effective result in the improvement of drug development. This review summarized the novel drugs, treatment phenomenon and overall condition of tuberculosis in Bangladesh.