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The Prevalence of Transfusion-transmitted Infections among Blood Donors in Hospital Universiti Sains Malaysia.

Authors
  • Ramli, Marini1, 2
  • Zulkafli, Zefarina1, 2
  • Chambers, Geoffrey Keith3
  • Zilan, Raja Sabrina Amani Raja2, 4
  • Edinur, Hisham Atan2, 4
  • 1 School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. , (Malaysia)
  • 2 Transfusion Medicine Unit, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Kelantan, Malaysia. , (Malaysia)
  • 3 School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand. , (New Zealand)
  • 4 School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia. , (Malaysia)
Type
Published Article
Journal
Oman medical journal
Publication Date
Nov 01, 2020
Volume
35
Issue
6
Identifiers
DOI: 10.5001/omj.2020.86
PMID: 33110633
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Blood bank centers routinely screen for hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) to ensure the safety of blood supply and thus prevent the dissemination of these viruses via blood transfusion. We sought to evaluate the detection of transfusion-transmitted infection (TTI) markers using standard serological methods and nucleic acid testing (NAT) among blood donors in Hospital Universiti Sains Malaysia. Donated blood units were assessed for the presence or absence of HBV, HCV, and HIV using two screening method: serology and NAT. Reactive blood samples were then subjected to serological confirmatory and NAT discriminatory assays. A total of 9669 donors were recruited from September 2017 to June 2018. Among these, 36 donors were reactive either for HBV, HCV, or HIV by serological testing and eight by NAT screening. However, only 10 (three for HBV and seven for HCV) donors tested positive using serological testing and five (two for HBV and three for HCV) by NAT discriminatory assays. Note that all five NAT positive donors detected in the NAT discriminatory assays were confirmed to be serologically reactive. Therefore, the prevalence of HBV, HCV, and HIV was 0.03%, 0.1%, and 0.0%, respectively, in our donor pool. Both serological and NAT screening and confirmatory assays should be used routinely to reduce the risk of infection transmission via the transfusion of blood and blood components. The OMJ is Published Bimonthly and Copyrighted 2020 by the OMSB.

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