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Prevalence of Sjögren’s syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases

  • Narváez, Javier1
  • Sánchez-Fernández, Simón Ángel2
  • Seoane-Mato, Daniel3
  • Díaz-González, Federico4
  • Bustabad, Sagrario4
  • 1 Hospital Universitario de Bellvitge, Feixa Llarga, s/n, Hospitalet de Llobregat, Barcelona, 08907, Spain , Barcelona (Spain)
  • 2 Complejo Hospitalario Mancha Centro, Alcázar de San Juan, Ciudad Real, Spain , Alcázar de San Juan (Spain)
  • 3 Sociedad Española de Reumatología, Madrid, Spain , Madrid (Spain)
  • 4 Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife, Spain , La Laguna (Spain)
Published Article
Scientific Reports
Springer Nature
Publication Date
Jun 30, 2020
DOI: 10.1038/s41598-020-67462-z
Springer Nature


To estimate the prevalence of Sjögren’s syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21–0.53). Extrapolating to the total population of the country aged ≥ 20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15–0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.

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