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Prevalence, self-awareness, and LDL cholesterol levels among patients highly suspected as familial hypercholesterolemia in a Japanese community.

  • Tada, Hayato1
  • Shibayama, Junichi1
  • Nishikawa, Tetsuo1
  • Okada, Hirofumi1
  • Nomura, Akihiro1
  • Usui, Soichiro1
  • Sakata, Kenji1
  • Hashiba, Atsushi2
  • Inazu, Akihiro3
  • Takamura, Masayuki1
  • Kawashiri, Masa-Aki1
  • 1 Department of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. , (Japan)
  • 2 Kanazawa Medical Association, Kanazawa, Japan. , (Japan)
  • 3 Department of Laboratory Science, Molecular Biochemistry and Molecular Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. , (Japan)
Published Article
Practical laboratory medicine
Publication Date
Nov 01, 2020
DOI: 10.1016/j.plabm.2020.e00181
PMID: 33134467


The prevalence of familial hypercholesterolemia (FH) among Japanese populations is still unclear. In addition, no prior data exist regarding the self-awareness. Accordingly, we aimed to investigate the prevalence, self-awareness, and LDL-C of patients with highly suspected as FH using data obtained in a community-based medical checkups. This study included 52,276 subjects (18,588 men, 35.6%) aged ≥40 years who underwent the Japanese specific health checkup in Kanazawa City during 2018. We assessed the self-awareness of dyslipidemia (and the age) as well as the prevalence of patients with highly suspected as FH whose naïve LDL-C levels were ≥250 ​mg/dl. Naïve LDL-C levels were estimated by the adjustment (LDL-C/0.7) for those on lipid-lowering medication. We divided subjects into 3 groups based on their naïve LDL cholesterol level (≥250 ​mg/dl, 140-249, and ≤139 ​mg/dl). We identified 262 (0.5%) individuals highly suspected as FH whose naïve LDL-C levels were ≥250 ​mg/dl. Most of them (234 among 262, 89%) were under lipid-lowering medication; however, the self-awareness as dyslipidemia was not quite high (200 among 262, 76%), and their mean LDL-C level under lipid-lowering medication was 203 ​± ​35 ​mg/dl. Interestingly, the age of acknowledgement of dyslipidemia among the patients with highly suspected as FH was significantly younger than those in other categories (58 vs. 60/62 ​yrs, respectively, p ​< ​0.05 for both). The prevalence of patients highly suspected as FH was around 1 in 200, and their self-awareness as well as control were not still good enough among Japanese general populations. © 2020 The Author(s).

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