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Prevalence and risk factors of Mycoplasma genitalium infection in patients attending a sexually transmitted infection clinic in Reunion Island: a cross-sectional study (2017–2018)

Authors
  • Begnis, Roxane1
  • Bouscaren, Nicolas2
  • Raffray, Loic3
  • Terrier, Cécile Saint Pastou1
  • Andry, Fanny1
  • Boukerrou, Malik4
  • Koumar, Yatrika1
  • Moiton, Marie-Pierre5
  • Gerardin, Patrick2
  • Bertolotti, Antoine1, 2
  • 1 Service des Maladies Infectieuses – Dermatologie, Saint Pierre, La Réunion, France , Saint Pierre (France)
  • 2 Inserm CIC1410, CHU Réunion, Saint Pierre, La Réunion, France , Saint Pierre (France)
  • 3 Service de Médecine Interne – Dermatologie, Saint Denis, La Réunion, France , Saint Denis (France)
  • 4 Service de Gynécologie et Obstétrique, Saint-Pierre, La Réunion, France , Saint-Pierre (France)
  • 5 Service des Maladies Infectieuses, Saint-Denis, La Réunion, France , Saint-Denis (France)
Type
Published Article
Journal
BMC Infectious Diseases
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 26, 2021
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12879-021-06193-6
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundMycoplasma genitalium (MG) is an emerging sexually transmitted infection (STI) for whose management remains controversial. We aimed to assess the prevalence and risk factors of MG infection in patients attending an STI clinic in Reunion Island.MethodsBetween January 2017 and December 2018, all patients attending the Saint-Pierre STI clinic in Reunion Island were screened for MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). Urogenital, pharyngeal and/or anal samples were collected based on sexual behaviour and analysed by triplex PCR. Risk factors were identified using a Poisson regression for binary outcome.ResultsAmong 2069 screened subjects, the overall prevalence of MG was 4.88% [95% Confidence Interval (CI) 3.98–5.93]. The prevalence of urogenital MG was 4.38%, with women being more affected than men (5.33% vs 3.22%, prevalence ratio (PR) 1.66, p = 0.02). The prevalence of anal MG was 3.06% and that of pharyngeal MG was 0.61%, with men being more affected in both cases. Infection with MG was independently associated with multiple partners (6–10 partners: adjusted prevalence ratio-aPR 2.55, p < 0.048; > 10 partners: aPR 4.33, p < 0.004), previous history of STI (aPR 1.89, p = 0.026), non-use of condoms (aPR 2.56, p < 0.003) and co-infection with CT (aPR 2.56, p < 0.017).ConclusionCompared to other countries, the prevalence of MG is high in Reunion Island, especially in women aged under 25 years, and co-infection with CT is common. Routine MG screening and treatment should be performed in at-risk women and co-infection with MG should be considered when deciding on treatment for CT, particularly in regions where azithromycin is still in use.

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