Affordable Access

Access to the full text

Prevalence and risk factors for chronic kidney disease of unknown cause in Malawi: a cross-sectional analysis in a rural and urban population

  • Hamilton, Sophie A.1, 1, 2
  • Nakanga, Wisdom P.3
  • Prynn, Josephine E.3, 4
  • Crampin, Amelia C.3, 5
  • Fecht, Daniela1, 1
  • Vineis, Paolo1, 1
  • Caplin, Ben4
  • Pearce, Neil5, 5
  • Nyirenda, Moffat J.3, 5
  • 1 Imperial College London, London, UK , London (United Kingdom)
  • 2 Imperial College London, School of Public Health, London, UK , London (United Kingdom)
  • 3 Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi , Lilongwe (Malawi)
  • 4 University College London, London, UK , London (United Kingdom)
  • 5 London School of Hygiene and Tropical Medicine, London, UK , London (United Kingdom)
Published Article
BMC Nephrology
Springer (Biomed Central Ltd.)
Publication Date
Sep 07, 2020
DOI: 10.1186/s12882-020-02034-x
Springer Nature


BackgroundAn epidemic of chronic kidney disease of unknown cause (CKDu) is occurring in rural communities in tropical regions of low-and middle-income countries in South America and India. Little information is available from Southern African countries which have similar climatic and occupational characteristics to CKDu-endemic countries. We investigated whether CKDu is prevalent in Malawi and identified its potential risk factors in this setting.MethodsWe conducted a cross-sectional study from January–August 2018 collecting bio samples and anthropometric data in two Malawian populations. The sample comprised adults > 18 years (n = 821) without diabetes, hypertension, and proteinuria. Estimates of glomerular filtration rate (eGFR) were calculated using the CKD-EPI equation. Linear and logistic regression models were applied with potential risk factors, to estimate risk of reduced eGFR.ResultsThe mean eGFR was 117.1 ± 16.0 ml/min per 1.73m2 and the mean participant age was 33.5 ± 12.7 years. The prevalence of eGFR< 60 was 0.2% (95% confidence interval (95% CI) 0.1, 0.9); the prevalence of eGFR< 90 was 5% (95% CI =3.2, 6.3). We observed a higher prevalence in the rural population (5% (3.6, 7.8)), versus urban (3% (1.4, 6.7)). Age and BMI were associated with reduced eGFR< 90 [Odds ratio (OR) (95%CI) =3.59 (2.58, 5.21) per ten-year increment]; [OR (95%CI) =2.01 (1.27, 3.43) per 5 kg/m2 increment] respectively. No increased risk of eGFR < 90 was observed for rural participants [OR (95%CI) =1.75 (0.50, 6.30)].ConclusionsReduced kidney function consistent with the definition of CKDu is not common in the areas of Malawi sampled, compared to that observed in other tropical or sub-tropical countries in Central America and South Asia. Reduced eGFR< 90 was related to age, BMI, and was more common in rural areas. These findings are important as they contradict some current hypothesis that CKDu is endemic across tropical and sub-tropical countries. This study has enabled standardized comparisons of impaired kidney function between and within tropical/subtropical regions of the world and will help form the basis for further etiological research, surveillance strategies, and the implementation and evaluation of interventions.

Report this publication


Seen <100 times