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Prevalence and resistance profiles of vancomycin-resistant enterococcal isolates in Iran; an eight-month report from nine major cities.

  • Armin, Shahnaz1
  • Zahedani, Shahram Shahraki2
  • Rahbar, Mohammad3
  • Azimi, Leila1
  • 1 Pediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 2 Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. , (Iran)
  • 3 Department of Microbiology, Iranian Reference Health Laboratory Research Centre, Ministry of Health and Medical Education, Tehran, Iran. , (Iran)
Published Article
Infectious disorders drug targets
Publication Date
Nov 11, 2019
DOI: 10.2174/1871526519666191112113753
PMID: 31721719


Enterococcal infections comprise a wide range of diseases with increasing importance due to the growing frequency of health-care-associated infections and increasing incidence of antimicrobial resistance. Vancomycin-resistant Enterococcus (VRE) is an emerging drug-resistant organism responsible for increasing numbers of nosocomial infections in both adults and children. Few data are available on the epidemiology and impact of VRE infections among Iranian children. In the present study, attempts were made to evaluate the prevalence and molecular characterization of VRE isolates from patients referred to several hospitals in Iran. Eight hundred and fourteen enterococcal clinical isolates from different patients were included in this cross-sectional study during June 2018 and February 2019. Antimicrobial susceptibility testing was performed by standard methods according to the Clinical Laboratories Standards Institute (CLSI) guidelines. The vanA and vanB genes in VRE isolates were amplified by PCR. A majority of the isolates (20.7%) were collected from hospitalized patients in ICU. Among all isolates, 254 (30%) were identified as VRE strains. All of VRE isolates were sensitive to linezolid. Moreover, only 39.9% of VRE isolates harbored vanA gene, while none of them carried the vanB gene. The present study reports the highest range of VRE infections in Iran. The constant surveillance and monitoring of VRE strains is recommended to limit the occurrence and spread of VRE clones within and between hospitals and community settings. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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