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The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis

Authors
  • Roels, Elodie1
  • Fastrès, Aline2
  • Merveille, Anne-Christine2
  • Bolen, Géraldine2
  • Teske, Erik3
  • Clercx, Cécile2
  • Mc Entee, Kathleen4
  • 1 Department of Internal Medicine, Pride Veterinary Centre, Derby, DE24 8HX, United Kingdom , Derby (United Kingdom)
  • 2 FARAH, University of Liege, Liege, 4000, Belgium , Liege (Belgium)
  • 3 Utrecht University, Utrecht, 3584 CL, The Netherlands , Utrecht (Netherlands)
  • 4 Université Libre de Bruxelles, Brussels, 1070, Belgium , Brussels (Belgium)
Type
Published Article
Journal
BMC Veterinary Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 23, 2021
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12917-021-02879-w
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundPulmonary hypertension (PH) is a known co-morbidity in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF). The pulmonary vein-to-right pulmonary artery ratio (PV/PA) has recently been described for the detection of pre-capillary PH in dogs. The objective of the present study was to estimate the prevalence of PH at diagnostic, in WHWTs affected with CIPF, by using PV/PA, in comparison with a group of healthy breed-matched controls (CTRLs). Additional study objective was to explore whether the presence of PH at initial diagnosis of CIPF impacted survival time in dogs treated with sildenafil.ResultsTwenty-five client-owned WHWTs presented with CIPF and 19 CTRLs were included in the study. PV/PA in either two-dimensional mode (2D) or time-motion mode or both were measured from cineloops in each dog. Dogs were classified according to PV/PA value into non/mild PH (PV/PA measured in 2D ≥ 0.7) or moderate/severe PH (PV/PA < 0.7). Survival data of WHWTs affected with CIPF were extracted from medical record to assess association between presence of PH at diagnosis and outcome. 60 % overall prevalence for moderate/severe PH was estimated in this cohort of WHWTs presented with CIPF vs. 5 % in CTRLS (P = 0.0002). The presence of moderate/severe PH at initial presentation was not associated with survival.ConclusionsResults of the present study confirm a high prevalence of PH at diagnosis in WHWTs affected with CIPF and highlight the utility of PV/PA as a non-invasive surrogate for assessment of PH in this population.

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