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Prevalence of psychological disorders, sleep disturbance and stressful life events and their relationships with disease parameters in Chinese patients with ankylosing spondylitis

Authors
  • Jiang, Yutong1
  • Yang, Mingcan1
  • Lv, Qing1
  • Qi, Jun1
  • Lin, Zhiming1
  • Liao, Zetao1
  • Zhang, Yanli1
  • Wu, Husheng2
  • Song, Hui2
  • Zhan, Feng3
  • Liu, Shengyun4
  • Gao, Guanmin4
  • Hu, Shaoxian5
  • Li, Yinong6
  • Shen, Lingxun7
  • Huang, Anbing7
  • Wei, Qiujing1
  • Cao, Shuangyan1
  • Gu, Jieruo1
  • 1 the Third Affiliated Hospital of Sun Yat-sen University, Department of Rheumatology and Immunology, 600 Tianhe Road, Guangzhou, 510630, China , Guangzhou (China)
  • 2 Beijing Jishuitan Hospital, Department of Rheumatology and Immunology, 31 Xinjiedong Street, Beijing, China , Beijing (China)
  • 3 Hainan General Hospital, Department of Rheumatology, 19 Xiuhua Road, Haikou, China , Haikou (China)
  • 4 the First Affiliated Hospital of Zhengzhou University, Department of Urology and Rheumatology, 1 Jianshedong Road, Zhengzhou, China , Zhengzhou (China)
  • 5 Huazhong University of Science and Technology, Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, 1095 Jiefang Road, Wuhan, China , Wuhan (China)
  • 6 Fuzhou General Hospital of Nanjing Military Command, Department of Rheumatology, 156 Xierhuanbei Road, Fuzhou, China , Fuzhou (China)
  • 7 Huazhong University of Science and Technology, Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, 1277 Jiefang Road, Wuhan, China , Wuhan (China)
Type
Published Article
Journal
Clinical Rheumatology
Publisher
Springer-Verlag
Publication Date
Nov 25, 2017
Volume
37
Issue
2
Pages
407–414
Identifiers
DOI: 10.1007/s10067-017-3907-z
Source
Springer Nature
Keywords
License
Yellow

Abstract

Our aim was to investigate the prevalence of psychological disorders, sleep disturbance, and stressful life events in Chinese patients with ankylosing spondylitis (AS) and healthy controls, to assess the correlation between psychological and disease-related variables, and finally to detect powerful factors in predicting anxiety and depression. AS patients diagnosed with the modified New York criteria and healthy controls were enrolled from China. Participants completed a set of questionnaires, including demographic and disease parameters, Zung self-rating anxiety scale (SAS), Zung self-rating depression scale (SDS), the Pittsburgh Sleep Quality Index questionnaire (PSQI), and the Social Readjustment Rating Scale (SRRS). The relationship between psychological and other variables was explored. Stepwise multiple regression was used to determine the contributors to each disorder. Of all the 2772 AS patients, 79.1% were male. Mean age was 28.99 ± 8.87 years. Prevalence of anxiety, depression, and sleep disturbance was 31.6% (95% CI, 29.9, to 33.4), 59.3% (95% CI, 57.5, to 61.2), and 31.0% (95% CI, 29.3, to 36.7), respectively. 35.3% had stimulus of psychological and social elements (SPSE). Compared with healthy controls, AS patients had more severe psychological disorders, sleep disturbance, and stressful life events (P < 0.01). SDS, overall pain, BASFI, and sleep disturbance were significant contributors of the SAS scores (P < 0.03). SAS, less years of education, and sleep duration were significant contributors of SDS (P < 0.01). AS patients had more anxiety, depression, stressful life events, and sleep disturbance than healthy controls. Pain, functional limitation, sleep disturbance, and education were major contributors to psychological disorders.

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