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Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS: a prospective multi-center study utilizing colonoscopy

Authors
  • Ishihara, Shunji1
  • Yashima, Kazuo2
  • Kushiyama, Yoshinori3
  • Izumi, Akio4
  • Kawashima, Kousaku5
  • Fujishiro, Hirofumi6
  • Kojo, Haruhiko7
  • Komazawa, Yoshinori8
  • Hamamoto, Tetsuro9
  • Yamamoto, Tetsuo10
  • Sasaki, Yuichiro11
  • Shimizu, Tatsunori12
  • Okamoto, Eiji13
  • Yoshimura, Teiji14
  • Furuta, Koichiro15
  • Noguchi, Naoya16
  • Tanaka, Hisao17
  • Murawaki, Yoshikazu2
  • Kinoshita, Yoshikazu1
  • 1 Shimane University, Department of Internal Medicine II, Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, Japan , Izumo (Japan)
  • 2 Tottori University, Division of Medicine and Clinical Science, Faculty of Medicine, Yonago, Japan , Yonago (Japan)
  • 3 Matsue Red Cross Hospital, Division of Gastroenterology, Matsue, Japan , Matsue (Japan)
  • 4 Izumi Gastrointestinal Clinic, Matsue, Japan , Matsue (Japan)
  • 5 Matsue Seikyo Hospital, Division of Internal Medicine, Matsue, Japan , Matsue (Japan)
  • 6 Shimane Prefectural Central Hospital, Division of Gastroenterology, Izumo, Japan , Izumo (Japan)
  • 7 Sanin Rosai Hospital, Division of Gastroenterology, Yonago, Japan , Yonago (Japan)
  • 8 Izumo City General Medical Center, Division of Internal Medicine, Izumo, Japan , Izumo (Japan)
  • 9 Hakuai Hospital, Division of Internal Medicine, Yonago, Japan , Yonago (Japan)
  • 10 Yonago Medical Center, Division of Internal Medicine, Yonago, Japan , Yonago (Japan)
  • 11 Saiseikai Sakaiminato General Hospital, Division of Internal Medicine, Sakaiminato, Japan , Sakaiminato (Japan)
  • 12 Tottori Prefectural Central Hospital, Division of Internal Medicine, Tottori, Japan , Tottori (Japan)
  • 13 Hamada Medical Center, Division of Gastroenterology, Hamada, Japan , Hamada (Japan)
  • 14 Matsue City Hospital, Division of Gastroenterology, Matsue, Japan , Matsue (Japan)
  • 15 Masuda Medical Association Hospital, Division of Internal Medicine, Masuda, Japan , Masuda (Japan)
  • 16 Tottori Prefectural Kousei Hospital, Division of Internal Medicine, Kurayoshi, Japan , Kurayoshi (Japan)
  • 17 Tottori Red Cross Hospital, Division of Internal Medicine, Tottori, Japan , Tottori (Japan)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Mar 30, 2012
Volume
47
Issue
10
Pages
1084–1090
Identifiers
DOI: 10.1007/s00535-012-0573-4
Source
Springer Nature
Keywords
License
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Abstract

BackgroundIt remains unknown whether the Rome III criteria can exclude organic colonic lesions prior to the diagnosis of irritable bowel syndrome (IBS). We evaluated the colonoscopy results of patients meeting the Rome III criteria for the diagnosis of IBS to determine the presence of organic colonic lesions.MethodsThis study was prospectively conducted at 17 centers in Japan. We enrolled 4528 patients who underwent diagnostic colonoscopy examinations. The diagnosis of IBS was evaluated by questionnaire results according to the Rome III criteria.ResultsWe evaluated 4178 patients (350 were excluded because of incomplete data or previous colonic surgery), of whom 203 met the Rome III criteria (mean age 57.9 years; range 14–87 years) prior to the diagnostic colonoscopy examination. We identified organic colonic diseases in 21 of these 203 patients (10.3 %) , and these disease were also identified in 338 (8.5 %) of 3975 patients who did not fulfill the Rome III criteria. There were no differences in regard to the prevalence of organic colonic diseases between patients who did and did not fulfill the Rome III criteria.ConclusionsThe prevalence of organic colonic diseases in patients who met the Rome III criteria was at an acceptably low level, indicating that the Rome III criteria are adequately specific for the diagnosis of IBS without performing a colonoscopy examination.

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