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Prevalence of functional haplotypes of the peptidylarginine deiminase citrullinating enzyme gene in patients with rheumatoid arthritis: no influence of the presence of anti-citrullinated peptide antibodies.

Authors
  • Faragó, B
  • Talián, G C
  • Maász, A
  • Magyari, L
  • Horvatovich, K
  • Kovács, B
  • Cserép, V
  • Kisfali, P
  • Kiss, C G
  • Czirják, L
  • Melegh, B
Type
Published Article
Journal
Clinical and experimental rheumatology
Publication Date
Jan 01, 2007
Volume
25
Issue
4
Pages
523–528
Identifiers
PMID: 17888206
Source
Medline
License
Unknown

Abstract

The data presented here show that none of the naturally occurring haplotypes of the PADI4 gene conferred susceptibility to RA in an average group of Hungarian patients; this is in agreement with findings for other European populations. In addition, none of the functional PADI4 haplotypes were associated with the pathologic immune response, which was evidenced by the absence of accumulation of anti-CCP-positive subjects in the specific PADI4 haplotypes.

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