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Prevalence and factors associated with pulmonary arterial hypertension on maintenance hemodialysis patients in Kinshasa, Democratic Republic of Congo: a cross-sectional study

  • Engole, Yannick Mompango1
  • Lepira, François Bompeka1
  • Nlandu, Yannick Mayamba1
  • Lubenga, Yves Simbi2
  • Longo, Augustin Luzayadio1
  • Nkodila, Aliocha1
  • Makulo, Jean-Robert Rissassy1
  • Mokoli, Vieux Momeme1
  • Bukabau, Justine Busanga1
  • Mboliasa, Marie-France Ingole1
  • Kadima, Evariste Mukendi1
  • Ilunga, Cedric Kabemba1
  • Mvunzi, Tresor Swambulu2
  • Nseka, Nazaire Mangani1
  • Sumaili, Ernest Kiswaya1
  • 1 University Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo , Kinshasa (Congo - Kinshasa)
  • 2 University Hospital of Kinshasa, BP: 123, Kinshasa, XI, Democratic Republic of the Congo , Kinshasa (Congo - Kinshasa)
Published Article
BMC Nephrology
Springer (Biomed Central Ltd.)
Publication Date
Nov 04, 2020
DOI: 10.1186/s12882-020-02131-x
Springer Nature


BackgroundAlthough cardiovascular diseases in particular Pulmonary Arterial Hypertension (PAH) is associated with, high morbid-mortality in chronic hemodialysis, but its magnitude remains paradoxically unknown in sub-Saharan Africa. The aim of this study was to evaluate the prevalence of PAH and associated factors in chronic hemodialysis in Sub-Saharan African population.MethodIn a cross-sectional study, patients treated with HD for at least 6 months in 4 hemodialysis centers were examined. PAH was defined as estimated systolic pulmonary arterial pressure (sPAP) ≥ 35 mmHg using transthoracic Doppler echocardiography performed 24 h after the HD session.ResultsEighty-five HD patients were included; their average age was 52.6 ± 15.9 years. Fifty-seven patients (67.1%) were male. Mean duration of HD was 13.3 ± 11 months. With reference to vascular access, 12 (14.1%), 29 (34.1%) and 44 (51.8%) patients had AVF, tunneled cuff and temporary catheter, respectively. The underlying cause of ESRD was diabetes in 30 patients (35.3%). The prevalence of PAH was 29.4%. Patients with PAH had more hyponatremia (11 (44%) vs 10 (16.7%), p = 0.010). In multivariate analysis, unsecured healthcare funding (aOR 4, 95% CI [1.18–6.018]), arrhythmia (aOR 3, 95% CI [1.29–7.34]), vascular access change (aOR 4, 95% CI [1.18–7.51]) and diastolic dysfunction (aOR 5, 95% CI [1.35–9.57] were independently associated with PAH.ConclusionOne third of hemodialysis patients exhibit PAH, which is independently associated with low socioeconomic status (unsecured funding, vascular access change) and cardiovascular complications (arrhythmia, diastolic dysfunction).

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