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Prevalence estimates for pyoderma gangrenosum in the United States: An age- and sex-adjusted population analysis.

Authors
  • Xu, Amy1
  • Balgobind, Amrita1
  • Strunk, Andrew1
  • Garg, Amit1
  • Alloo, Allireza2
  • 1 Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.
  • 2 Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York. Electronic address: [email protected]
Type
Published Article
Journal
Journal of the American Academy of Dermatology
Publication Date
Aug 01, 2020
Volume
83
Issue
2
Pages
425–429
Identifiers
DOI: 10.1016/j.jaad.2019.08.001
PMID: 31400451
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The disease burden of pyoderma gangrenosum (PG) is poorly understood. To determine standardized overall and age-, sex-, and race-specific prevalence estimates for PG among adults in the United States. Cross-sectional analysis of 1971 patients with PG identified using electronic health records data from a diverse population-based sample of more than 58 million patients. The age- and sex-standardized prevalence of PG among the study population was 0.0058%, or 5.8 PG cases (95% confidence interval [CI], 5.6-6.1) per 100,000 adults. Adjusted prevalence was nearly twice as high among women (7.1 cases [95% CI, 6.7-7.5] per 100,000) than men (4.4 cases [95% CI, 4.0-4.7] per 100,000). Patients between the ages of 70 and 79 years had the highest standardized prevalence (9.8 cases [95% CI, 8.8-10.9] per 100,000), with patients aged ≥50 years representing nearly 70% of all PG cases. Standardized prevalence was similar among white and African American patients. The female-to-male ratio of PG was >1.8 across all age groups. Analysis of electronic health records data may result in misclassification bias. PG is a rare disease that most commonly affects women and those aged ≥50 years. Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

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