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Prevalence, Distribution and IgG Antibody Levels Associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Among Health-System and Community-Based Employees and Patients

  • Kabagambe, Edmond K1, 2
  • Velasco-Gonzalez, Cruz2
  • Henry, Marcia B.1
  • Fort, Dan2
  • Wu, Qingli3
  • Sossaman, Gregory3
  • Laborde, Yvens4
  • Price-Haywood, Eboni1, 2, 5
  • Roberts, W. Mark1
  • Seoane, Leonardo1, 5
  • 1 Division of Academics, Ochsner Health, New Orleans, LA
  • 2 Ochsner Center for Outcomes Research, Division of Academics, Ochsner Health, New Orleans, LA
  • 3 Department of Pathology, Ochsner Health, New Orleans, LA
  • 4 Global Health Education, Ochsner Health, New Orleans, LA
  • 5 University of Queensland Ochsner Clinical School, Ochsner Health, New Orleans, LA
Published Article
The American Journal of the Medical Sciences
Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
Publication Date
Oct 01, 2021
DOI: 10.1016/j.amjms.2021.09.006
PMID: 34606754
PMCID: PMC8485713
PubMed Central
  • Clinical Investigation


Background Following the high morbidity and mortality due to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections in New Orleans, Louisiana, we sought to assess progress toward herd immunity. Methods Ochsner Health employees and patients who volunteered for Abbott SARS-CoV-2 IgG antibody test between March 1 and May 1, 2020 were included. We estimated IgG prevalence and used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for variables associated with IgG test status. Results Of the 13,343 participants with IgG test results, 78.6% were women, 70.6% were non-Hispanic White, 21.1% non-Hispanic Black, 2.9% Hispanic Americans and 5.4% belonged to other races. Overall, 7.99% (95% CI: 7.53-8.45%) of the participants tested IgG positive. In age-, sex- and body mass index (BMI)-adjusted analyses, non-Hispanic Blacks were 2.7-times more likely to test positive than non-Hispanic Whites (OR=2.72; 95% CI: 2.33-3.19). Corresponding ORs (95% CIs) were 1.29 (0.84-1.99) for Hispanic Americans and 1.22 (0.85-1.75) for Other race/ethnicities. Compared to participants in administrative occupations, physician assistants (OR=7.14; 95% CI: 1.72-29.6) and therapists (OR=4.74; 95% CI: 1.49-15.03) were significantly more likely to have IgG antibodies while the association among nurses was not significant (OR=2.35; 95% CI: 0.96-5.77). Relative to 1.40, the test threshold for positivity, our measurements indicate a strong immune response (5.38±1.69), especially among those with a higher BMI. Conclusions SARS-COV-2 IgG antibodies were prevalent only in 8% of the participants. IgG prevalence was highest among non-Hispanic Blacks and participants with higher BMI but was lower among older participants.

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