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Prevalence of cutaneous viral infections in incident cutaneous squamous cell carcinoma detected among chronic lymphocytic leukemia and hematopoietic stem cell transplant patients.

Authors
  • Hampras, Shalaka S1
  • Locke, Frederick L2
  • Chavez, Julio C3
  • Patel, Nishit S4
  • Giuliano, Anna R1, 5
  • Miller, Kyle6
  • Gheit, Tarik7
  • Tommasino, Massimo7
  • Rollison, Dana E1, 5
  • 1 a Department of Cancer Epidemiology , Moffitt Cancer Center , Tampa , FL , USA.
  • 2 b Department of Blood and Marrow Transplant and Cellular Immunotherapy , Moffitt Cancer Center , Tampa , FL , USA.
  • 3 c Department of Malignant Hematology , Moffitt Cancer Center , Tampa , FL , USA. , (Mali)
  • 4 d Department of Dermatology and Cutaneous Surgery, Morsani College of Medicine , University of South Florida , Tampa , FL , USA.
  • 5 e Center for Infection Research in Cancer , Moffitt Cancer Center , Tampa , Florida , USA.
  • 6 f College of Agriculture and Life Sciences, University of Florida, Gainesville , Tampa , FL , USA.
  • 7 g Infections and Cancer Biology Group , International Agency for Research on Cancer-World Health Organization , Lyon , France. , (France)
Type
Published Article
Journal
Leukemia & Lymphoma
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2018
Volume
59
Issue
4
Pages
911–917
Identifiers
DOI: 10.1080/10428194.2017.1342822
PMID: 28679298
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The role of cutaneous viral infections in the development of non-melanoma skin cancer (NMSC), including cutaneous squamous cell carcinoma (SCC), among chronic lymphocytic leukemia (CLL) and blood and marrow transplant (BMT) patients is not established. CLL (n = 977) and BMT (n = 3587) patients treated at the Moffitt Cancer Center were included in a retrospective cohort study. Human papillomavirus (HPV) and human polyomavirus (HPyV) DNA were examined in a subset of incident SCC tumors. Five-year cumulative incidence of NMSC was 1.42% in both BMT (n = 31 NMSCs) and CLL (n = 18 NMSCs) cohorts. Of the nine SCC tumors examined from each cohort, 22.2% and 33.3% were positive for viral DNA in the transplant (HPV 65, MCV) and CLL (HPV 38, HPV 15, HPyV6) cohort, respectively. Enhanced skin cancer screening of BMT/CLL patients should be conducted to better capture incident NMSCs and examine the role of viral infections in these tumors.

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