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Prevalence of COVID infections in a population of rheumatic patients from Lombardy and Marche treated with biological drugs or small molecules: A multicentre retrospective study

Authors
  • Sarzi-Puttini, Piercarlo1
  • Marotto, Daniela1
  • Caporali, Roberto2
  • Montecucco, Carlo Maurizio3
  • Favalli, Ennio Giulio2
  • Franceschini, Franco4
  • Fredi, Michela4
  • Balduzzi, Silvia3
  • Bazzani, Chiara4
  • Bongiovanni, Sara1
  • Giorgi, Valeria1
  • Batticciotto, Alberto5
  • Cappelli, Antonella5
  • Balzarini, Patrizia5
  • Dagna, Lorenzo6, 7
  • Sartorelli, Silvia6, 7
  • Ravagnani, Viviana8
  • Tamanini, Silvia8
  • Farah, Sonia9
  • Faggioli, Paola10, 11
  • And 4 more
  • 1 Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy
  • 2 Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy
  • 3 Rheumatology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • 4 Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
  • 5 Rheumatology Unit Ospedale di Circolo - Fondazione Macchi, ASST dei Sette Laghi, Varese, Italy
  • 6 Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR) IRCCS San Raffaele Scientific Institute, Milan, Italy
  • 7 Vita-Salute San Raffaele University, Milan, Italy
  • 8 SSD Allergologia e Immunologia Clinica, ASST Mantova, Italy
  • 9 Rheumatological Clinic, Ospedale “Carlo Urbani”, Università Politecnica delle Marche, Jesi, Ancona, Italy
  • 10 Department of Internal Medicine ASST Ovest Milanese, Legnano, Italy
  • 11 Rheumatology Department ASST Ovest Milanese, Magenta, Italy
  • 12 Department of Clinical and Biomedical Sciences “Luigi Sacco”, University of Milano, Milano, Italy
  • 13 III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milano, Italy
Type
Published Article
Journal
Journal of Autoimmunity
Publisher
Elsevier
Publication Date
Sep 22, 2020
Volume
116
Pages
102545–102545
Identifiers
DOI: 10.1016/j.jaut.2020.102545
PMID: 32972804
PMCID: PMC7506330
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Rheumatic patients are at risk of developing infections because their immunocompromised state. • Biologics or small-molecules would not appear to be related to increased or reduced susceptibility of COVID-19. • DMARDS (traditional and biologics) and small molecules can be probably used at different timings of the disease. • The use of immunosuppressant for prophylaxis of COVID-19 is still a matter of debate. • Patient surveillance and the endorsement of extensive preventive barrier measures is mandatory.

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