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Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitis

Authors
  • Christina Duftner
  • Christian Goldberger
  • Albrecht Falkenbach
  • Reinhard Würzner
  • Barbara Falkensammer
  • Karl P Pfeiffer
  • Elisabeth Maerker-Hermann
  • Michael Schirmer
Publisher
BioMed Central
Publication Date
Jan 01, 2003
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Circulating CD3+CD4+CD28- cells exhibit reduced apoptosis and were found to be more enriched in patients with ankylosing spondylitis than in age-matched healthy control individuals (7.40 ± 6.6% versus 1.03 ± 1.0%; P < 0.001). Levels of CD4+CD28- T cells correlate with disease status as measured using a modified metrology score, but they are independent of age and duration of ankylosing spondylitis. CD4+CD28- T cells produce IFN-γ and perforin, and thus they must be considered proinflammatory and cytotoxic. These T cells share phenotypic and functional properties of natural killer cells, strongly expressing CD57 but lacking the lymphocyte marker CD7. MHC class I recognizing and activating natural killer cell receptors on the surface of CD4+CD28- T cells may be involved in a HLA-B27 mediated co-stimulation of these proinflammatory and cytotoxic cells.

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