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Prevalence of antibody against non-A, non-B hepatitis virus in Japanese patients with hepatocellular carcinoma.

Authors
  • Ohkoshi, S1
  • Kojima, H
  • Tawaraya, H
  • Miyajima, T
  • Kamimura, T
  • Asakura, H
  • Satoh, A
  • Hirose, S
  • Hijikata, M
  • Kato, N
  • 1 Third Department of Internal Medicine School of Medicine, Niigata University.
Type
Published Article
Journal
Japanese journal of cancer research : Gann
Publication Date
Jan 01, 1990
Volume
81
Issue
6-7
Pages
550–553
Identifiers
PMID: 2169469
Source
Medline
Language
English
License
Unknown

Abstract

Antibodies against a possible causative agent of non-A, non-B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme-linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)-negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg-positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg-negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody-positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti-HCV antibody and HBsAg-negative hepatocellular carcinoma in Japan.

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