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Pretreatment with Empty Liposomes Attenuates the Immunopathology of Invasive Pulmonary Aspergillosis in Corticosteroid-Immunosuppressed Mice▿

Authors
  • Russell E. Lewis
  • Georgios Chamilos
  • Randall A. Prince
  • Dimitrios P. Kontoyiannis
Publisher
American Society for Microbiology
Publication Date
Dec 28, 2006
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to 1 mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.

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