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Pretreatment of simvastatin on liver trace element levels during endotoxemia.

Authors
  • Yorulmaz, Hatice1
  • Ozkok, Elif2
  • Demir, Goksel3
  • Ertugrul Yalcin, Ibrahim4
  • Ates, Gulten5, 6
  • Olgac, Vakur7
  • Tamer, Sule6
  • 1 School of Nursing, Halic University, Istanbul, Turkey. , (Turkey)
  • 2 Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 3 Department of Urban, and Regional Planning, Faculty of Architecture, Kirklareli University, Kirklareli, Turkey. , (Turkey)
  • 4 Department of Molecular Biology, and Genetics, Faculty of Engineering and Natural Sciences, Bahcesehir University, Istanbul, Turkey. , (Turkey)
  • 5 Department of Physiology, Faculty of Medicine, Istanbul Yeni Yuzyil University, Istanbul, Turkey. , (Turkey)
  • 6 Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 7 Department of Pathology, Oncology Institute, Istanbul University, Istanbul, Turkey. , (Turkey)
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Jul 01, 2020
Volume
126
Issue
3
Pages
196–200
Identifiers
DOI: 10.1080/13813455.2018.1508234
PMID: 30450988
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels was evaluated in liver during endotoxemia. Rats were divided into control, LPS, simvastatin, and simvastatin + LPS. The histopathologic examination of the liver was performed using hematoxylin and eosin. Selenium, zinc, iron, manganese, magnesium, and copper were analyzed using inductively coupled plasma - optical emission spectroscopy. In the LPS, the hepatocyte cell structure was damaged. In the simvastatin + LPS, hepatocyte, and sinusoidal cord damage were partially smaller than LPS. Levels of selenium, and copper significantly decreased in both of LPS and simvastatin + LPS. In the LPS group, iron was found to increase. In the simvastatin + LPS, zinc was increased. Simvastatin partially smaller liver damage by increasing zinc levels during endotoxemia.

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