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Pretreatment of Shaoyao Gancao Decoction (芍药甘草汤) alters pharmacokinetics of intravenous paclitaxel in rats

Authors
  • Wang, Yang1
  • Huang, Xi1
  • Zhong, Mei-zuo2
  • Lu, Ruo-huang3
  • Xia, Zi-an1
  • Fan, Rong1
  • Liu, Bo4
  • Huang, Wei1
  • Gan, Ping-ping2
  • 1 Central South University, Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Changsha, 410008, China , Changsha (China)
  • 2 Central South University, Department of Oncology, Xiangya Hospital, Changsha, 410008, China , Changsha (China)
  • 3 Central South University, Department of Stomatology, the Third Xiangya Hospital, Changsha, 410008, China , Changsha (China)
  • 4 Central South University, Department of geriatrics, Xiangya Hospital, Changsha, 410008, China , Changsha (China)
Type
Published Article
Journal
Chinese Journal of Integrative Medicine
Publisher
Springer Berlin Heidelberg
Publication Date
Sep 27, 2016
Volume
23
Issue
1
Pages
70–75
Identifiers
DOI: 10.1007/s11655-016-2619-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveTo investigate the effect of Shaoyao Gancao Decoction (芍药甘草汤, SGD) on the pharmacokinetics of intravenously administered paclitaxel in rats.MethodsPaclitaxel was intravenously administered to rats (3 mg/kg) with or without the concomitant administration of SGD (752 mg/kg, a single day or 14 consecutive days pretreatment). The paclitaxel in the serum was quantified using a simple and rapid ultra performance liquid chromatography (UPLC) method for the pharmacokinetic study. The pharmacokinetic parameters were calculated via a non-compartment model using the computer program DAS 2.0.ResultsThe pharmacokinetic parameters of paclitaxel were significantly altered in response to 14 consecutive days of pretreatment with SGD. The area under the curve (AUC0-t, from 4 820±197 to 4 205±186 ng·mL-1·-1) and AUC0-∞ (from 5 237±280 to 4 514±210 ng·mL-1·-1) significantly decreased in response to the 14-day pretreatment with SGD. The values of Vdss (L/kg) were 10.74±1.08 and 9.35±0.49, those of CL (L/kg) were 0.67±0.03 and 0.57±0.03 and the t1/2 (h) values were 11.17±0.84 and 11.32±0.93, respectively, for the 14-day SGD pretreatment and intravenous paclitaxel alone. The AUC0-t and AUC0-∞ values decreased by 13% and 14% (P<0.01), respectively. The area under the curve decreased signifificantly (P<0.01), and the total clearance increased by 1.2-fold (P<0.01), after 14 consecutive days of pretreatment with SGD. A single-day pretreatment with SGD did not signifificantly affect the pharmacokinetic parameters of paclitaxel.ConclusionsSGD administration for 14 consecutive days increased the metabolism of paclitaxel, while a 1-day pretreatment had little effect. The results would contribute important information to the study on interaction between Chinese medicines and chemotherapy and also help to utilize SGD better in the adjunctive therapy of cancer patients.

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