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Pretreatment of Shaoyao Gancao Decoction () alters pharmacokinetics of intravenous paclitaxel in rats.

Authors
  • Wang, Yang1
  • Huang, Xi1
  • Zhong, Mei-Zuo2
  • Lu, Ruo-Huang3
  • Xia, Zi-An1
  • Fan, Rong1
  • Liu, Bo4
  • Huang, Wei1
  • Gan, Ping-Ping5
  • 1 Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. , (China)
  • 2 Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. , (China)
  • 3 Department of Stomatology, the Third Xiangya Hospital, Central South University, Changsha, 410008, China. , (China)
  • 4 Department of geriatrics, Xiangya Hospital, Central South University, Changsha, 410008, China. , (China)
  • 5 Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China. [email protected] , (China)
Type
Published Article
Journal
Chinese journal of integrative medicine
Publication Date
Jan 01, 2017
Volume
23
Issue
1
Pages
70–75
Identifiers
DOI: 10.1007/s11655-016-2619-6
PMID: 27679442
Source
Medline
Keywords
License
Unknown

Abstract

SGD administration for 14 consecutive days increased the metabolism of paclitaxel, while a 1-day pretreatment had little effect. The results would contribute important information to the study on interaction between Chinese medicines and chemotherapy and also help to utilize SGD better in the adjunctive therapy of cancer patients.

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