Affordable Access

Pretreatment with a potassium-channel opener before prolonged cardiac storage: an evaluation in an experimental brain death model.

Authors
  • Kirsch, M1
  • Bertrand, S
  • Garnier, J P
  • Fernandez, C
  • Baufreton, C
  • Astier, A
  • Loisance, D
  • 1 Centre de Recherches Chirurgicales Henri Mondor and the Pharmacie Centrale, Hôpital Henri Mondor, Créteil, France.
Type
Published Article
Journal
The Annals of Thoracic Surgery
Publisher
Elsevier
Publication Date
June 1999
Volume
67
Issue
6
Identifiers
PMID: 10391265
Source
Medline
License
Unknown

Abstract

Systolic function and diastolic function were significantly altered in hearts explanted from brain-dead rabbits compared with hearts from rabbits having a sham operation. Cromakalim pretreatment had no significant effect on poststorage systolic or diastolic function of hearts explanted from brain-dead or sham-operation rabbits. Further, cromakalim pretreatment did not affect coronary flow or overall creatine kinase release during reperfusion. CONCLUSIONS; In vivo pretreatment of brain-dead rabbits or anesthetized rabbits with an intravenous injection of cromakalim had no significant effect on functional recovery of or enzymatic release from explanted hearts after 5 hours' hypothermic storage and 60 minutes' reperfusion. These findings underscore the importance of clinically relevant experimental models.

Report this publication

Statistics

Seen <100 times