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Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.

Authors
  • Sato, Noriko
  • Hassan, Raffit
  • Axworthy, Donald B
  • Wong, Karen J
  • Yu, Sarah
  • Theodore, Louis J
  • Lin, Yukang
  • Park, Luke
  • Brechbiel, Martin W
  • Pastan, Ira
  • Paik, Chang H
  • Carrasquillo, Jorge A
Type
Published Article
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Publication Date
Jul 01, 2005
Volume
46
Issue
7
Pages
1201–1209
Identifiers
PMID: 16000290
Source
Medline
License
Unknown

Abstract

SS1scFvSA localized in the mesothelin-expressing tumor, resulting in a high accumulation of radiolabeled DOTA-biotin. The specific activity of DOTA-biotin had a significant effect on its tumor uptake. Therapeutic tumor doses were obtained without dose-limiting toxicity.

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