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The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.

Authors
Type
Published Article
Journal
Genetic testing and molecular biomarkers
Publication Date
Volume
15
Issue
9
Pages
645–651
Identifiers
DOI: 10.1089/gtmb.2010.0258
PMID: 21721932
Source
Medline

Abstract

None of the investigated SNPs clearly predicted outcome of sepsis-related multiorgan failure. TLR2-R753Q SNP may be a useful marker to identify patients with high risk to develop infections at ICU admission but should be validated in larger studies. Future SNP-arrays investigating predisposition for infection should include this SNP alone or in combination with other functionally relevant SNPs.

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