Affordable Access

deepdyve-link
Publisher Website

The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.

Authors
  • Ahmad-Nejad, Parviz
  • Denz, Christof
  • Zimmer, Wilma
  • Wacker, Jennifer
  • Bugert, Peter
  • Weiss, Christel
  • Quintel, Michael
  • Neumaier, Michael
Type
Published Article
Journal
Genetic Testing and Molecular Biomarkers
Publisher
Mary Ann Liebert
Publication Date
Sep 01, 2011
Volume
15
Issue
9
Pages
645–651
Identifiers
DOI: 10.1089/gtmb.2010.0258
PMID: 21721932
Source
Medline
License
Unknown

Abstract

None of the investigated SNPs clearly predicted outcome of sepsis-related multiorgan failure. TLR2-R753Q SNP may be a useful marker to identify patients with high risk to develop infections at ICU admission but should be validated in larger studies. Future SNP-arrays investigating predisposition for infection should include this SNP alone or in combination with other functionally relevant SNPs.

Report this publication

Statistics

Seen <100 times