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Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.

Authors
  • Volz, A
  • Weiss, E
  • Trowsdale, J
  • Ziegler, A
Type
Published Article
Journal
Human genetics
Publication Date
Jan 01, 1994
Volume
93
Issue
1
Pages
42–46
Identifiers
PMID: 8270253
Source
Medline
License
Unknown

Abstract

An expressed beta-tubulin gene (TUBB) has previously been localized to chromosome region 6pter-p21 in man. By using a panel of deletion mutant cell lines and radiation-reduced hybrids containing fragments of chromosome 6, the TUBB locus could be mapped to the HLA class I region at 6p21.3. A long range restriction map including TUBB and several HLA class I genes was then generated by rotating field gel electrophoresis. The results show that TUBB maps to a segment 170-370 kb telomeric of HLA-C. This location suggests that a mutation at the TUBB locus could be the cause for certain forms of HLA-linked microtubule dysfunction, including immotile cilia syndrome.

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