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Presence of dynapenia and association with anthropometric variables in cancer patients

Authors
  • Rechinelli, Ana Beatriz1
  • Marques, Isabele Lessa1
  • de Morais Viana, Eduarda Cristina Rodrig...1
  • da Silva Oliveira, Isadora1
  • de Souza, Vanusa Felício1
  • Petarli, Glenda Blaser2
  • Rocha, Jose Luiz Marques1, 3
  • Guandalini, Valdete Regina1, 3
  • 1 Federal University of Espirito Santo, Vitoria, Espırito Santo, Brazil. Marechal Campos avenue, 1468 – Maruípe, Vitória, Espírito Santo, CEP: 29040-090, Brazil , Vitória (Brazil)
  • 2 University Cassiano Antonio Moraes Hospital, Vitoria, Espırito Santo, Brazil. Marechal Campos avenue, 1355 – Santa Cecília, Vitória, Espírito Santo, CEP: 29043-260, Brazil , Vitória (Brazil)
  • 3 Federal University of Espirito Santo, Vitoria, Espırito Santo, Brazil. Avenida Marechal Campos avenue, 1468 – Maruípe, Vitória, Espírito Santo, CEP: 29040-090, Brazil , Vitória (Brazil)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 19, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12885-020-07519-4
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundDynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analyze the presence of dynapenia and its association with anthropometric variables in hospitalized cancer patients.MethodsParticipants comprised adult and elderly cancer patients evaluated within the first 48 h of hospital admission to a tertiary public hospital, a referral center for gastrointestinal tract surgery. Anthropometric variables were measured according to standardized protocols. Dynapenia was identified based on handgrip strength (HGS), according to the cutoff points defined by the European Working Group on Sarcopenia in Older People (EWGSOP2), with values for women < 16 kg and for men < 27 kg. Statistical analysis was performed using SPSS software, version 22.0, with a significance level of 5%.ResultsThis study included 158 patients aged in average 59.5 ± 14.0 years; of these, 53.6% were elderly, 58.9% non-white and 59.5% had some degree of malnutrition. The most prevalent type of cancer was that of the lower gastrointestinal tract (33.5%). The presence of dynapenia was observed in 23.4% of the patients and cachexia in 36.1%. There was an association between dynapenia with age (p < 0.001), life stage (p = 0.002) and race/color (p = 0.027), and also with body mass index (BMI) (p = 0.001) and adductor pollicis muscle thickness (APMT) of both hands (p < 0.05). After logistic regression analysis, adjusted for the sociodemographic variables, the APMT of the dominant hand and the low weight determined by body mass index remained associated with the occurrence of dynapenia (p < 0.05).ConclusionsIn this study we confirmed that dynapenia was present in cancer patients, being associated with APMT of the dominant hand and low weight. HSG was proven to be a reliable and complementary measure to be added to the process of assessing nutritional status, contributing to the nutritional diagnosis of these patients and to the detection of early muscle depletion.

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