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Preparation, purification, and characterization of a reversibly lipidized desmopressin with potentiated anti-diuretic activity.

Authors
  • Wang, J
  • Shen, D
  • Shen, W C
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Nov 01, 1999
Volume
16
Issue
11
Pages
1674–1679
Identifiers
PMID: 10571271
Source
Medline
License
Unknown

Abstract

The 250-fold increase of the anti-diuretic potency in DPP is most likely due to a slow elimination and prolonged tissue retention, together with the regeneration of active DDAVP, in the animals. Our results indicate that reversible lipidization is a simple and effective approach for improving the efficacy of many peptide drugs.

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