Preparation, purification, and characterization of a reversibly lipidized desmopressin with potentiated anti-diuretic activity.
- Published Article
- Publication Date
Nov 01, 1999
The 250-fold increase of the anti-diuretic potency in DPP is most likely due to a slow elimination and prolonged tissue retention, together with the regeneration of active DDAVP, in the animals. Our results indicate that reversible lipidization is a simple and effective approach for improving the efficacy of many peptide drugs.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10571271