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Preparation of inactivated oil-emulsion vaccines with avian viral or Mycoplasma antigens.

Authors
  • Stone, H D
  • Brugh, M
  • Hopkins, S R
  • Yoder, H W
  • Beard, C W
Type
Published Article
Journal
Avian diseases
Publication Date
Jan 01, 1978
Volume
22
Issue
4
Pages
666–674
Identifiers
PMID: 219830
Source
Medline
License
Unknown

Abstract

The influence of the composition of water-in-oil emulsions on their physical characteristics was determined by preparing experimental emulsions with various water-to-oil ratios and various emulsifiers. Emulsions containing Tween 80 in the aqueous phase and Arlacel A or Arlacel 80 in the oil phase were lower in viscosity than emulsions containing only an oil-phase emulsifier. Viscosity decreased as the concentration of oil increased. Oil-emulsion vaccines prepared with aqueous- and oil-phase emulsifiers had low viscosity, were stable for more than 12 weeks at 37 C, and induced a marked primary antibody response in chickens.

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