Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

Mark E Flanagan; Steven J Brickner; Manjinder Lall; Jeffrey Casavant; Laura Deschenes; Steven M Finegan; David M George; Karl Granskog; Joel R Hardink; Michael D Huband; Thuy Hoang; Lucinda Lamb; Andrea Marra; Mark Mitton-Fry; John P Mueller; Lisa M Mullins; Mark C Noe; John P O'Donnell; David Pattavina; Joseph B Penzien; Brandon P Schuff; Jianmin Sun; David A Whipple; Jennifer Young; Thomas D Gootz

doi:10.1021/ml200012f

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Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

Authors

Flanagan, Mark E
Brickner, Steven J
Lall, Manjinder
Casavant, Jeffrey
Deschenes, Laura
Finegan, Steven M
George, David M
Granskog, Karl
Hardink, Joel R
Huband, Michael D
Hoang, Thuy
Lamb, Lucinda
Marra, Andrea
Mitton-Fry, Mark
Mueller, John P
Mullins, Lisa M
Noe, Mark C
O'Donnell, John P
Pattavina, David
Penzien, Joseph B
Schuff, Brandon P
Sun, Jianmin
Whipple, David A
Young, Jennifer
Gootz, Thomas D

And 5 more

Type

Published Article

Journal

ACS Medicinal Chemistry Letters

Publisher

American Chemical Society

Publication Date

May 12, 2011

Volume

2

Issue

5

Pages

385–390

Identifiers

DOI: 10.1021/ml200012f

PMID: 24900319

Source

Medline

Keywords

License

Unknown

Abstract

A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/04/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24900319

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