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Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols.

Authors
  • Flanagan, Mark E
  • Brickner, Steven J
  • Lall, Manjinder
  • Casavant, Jeffrey
  • Deschenes, Laura
  • Finegan, Steven M
  • George, David M
  • Granskog, Karl
  • Hardink, Joel R
  • Huband, Michael D
  • Hoang, Thuy
  • Lamb, Lucinda
  • Marra, Andrea
  • Mitton-Fry, Mark
  • Mueller, John P
  • Mullins, Lisa M
  • Noe, Mark C
  • O'Donnell, John P
  • Pattavina, David
  • Penzien, Joseph B
  • And 5 more
Type
Published Article
Journal
ACS Medicinal Chemistry Letters
Publisher
American Chemical Society
Publication Date
May 12, 2011
Volume
2
Issue
5
Pages
385–390
Identifiers
DOI: 10.1021/ml200012f
PMID: 24900319
Source
Medline
Keywords
License
Unknown

Abstract

A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.

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