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Preparation of epigallocatechin gallate decorated Au-Ag nano-heterostructures as NIR-sensitive nano-enzymes for the treatment of osteoarthritis through mitochondrial repair and cartilage protection.

Authors
  • Xu, Shibo1
  • Chang, Linna1
  • Zhao, Xingjun1
  • Hu, Yanan1
  • Lin, Yiyi1
  • Chen, Zhenhua2
  • Ren, Xiuli3
  • Mei, Xifan4
  • 1 Jinzhou Medical University, Jinzhou, 121001, Liaoning, China. , (China)
  • 2 Jinzhou Medical University, Jinzhou, 121001, Liaoning, China. Electronic address: [email protected] , (China)
  • 3 Jinzhou Medical University, Jinzhou, 121001, Liaoning, China. Electronic address: [email protected] , (China)
  • 4 Jinzhou Medical University, Jinzhou, 121001, Liaoning, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Acta biomaterialia
Publication Date
Mar 28, 2022
Identifiers
DOI: 10.1016/j.actbio.2022.03.038
PMID: 35358735
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Osteoarthritis (OA), a widespread degenerative disease characterized by cartilage destruction, has emerged as a public health challenge in the current aging society. In addition to applied steroids and surgery, near-infrared (NIR) sensitive nano-enzyme for the treatment of osteoarthritis through mitochondrial repair and cartilage protection is attractive and promising. In this study, a NIR sensitive multifunctional heterostructure (EGCG (Epigallocatechin gallate) decorated Au-Ag nano-jars ([email protected])) was introduced as an enzyme-sensitive active nanoplatform for the treatment of osteoarthritis. Molecular biology results indicated that [email protected] possesses intrinsic properties of anti-oxidative stress and was able to reduce the apoptosis rate of chondrocytes by 83.3%. The area of the intra-articular joint cavity injected with [email protected] can be elevated to 46.6 °C under NIR to promote the release of EGCG further to induce cartilage regeneration. X-ray radiography and section staining showed that [email protected] reduced cartilage damage and decreased OARSI scores by approximately 52% after 8 weeks of treatment in a surgically induced OA model. The results demonstrated that this multifunctional enzyme-like nanoplatform with a synergistic NIR sensitive property to facilitate cartilage migration and regeneration repair provides a promising OA treatment strategy. STATEMENT OF SIGNIFICANCE: 1. NIR-sensitive nano-enzyme is gaining much attention in the field of biomedical materials. 2. EGCG decorated Au-Ag nano-heterostructures were utilized as NIR-sensitive nano-enzymes for the treatment of osteoarthritis through mitochondrial repair and cartilage protection. 3. The obtained multifunctional Au-Ag nano-heterostructures are promising for osteoarthritis treatment. Copyright © 2022. Published by Elsevier Ltd.

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