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Preparation of core particles for aqueous film coating using agitation fluidized bed.

Authors
Type
Published Article
Journal
Chemical & pharmaceutical bulletin
Publication Date
Volume
45
Issue
12
Pages
2039–2042
Identifiers
PMID: 9433775
Source
Medline
License
Unknown

Abstract

Core particles used for aqueous film coating were prepared by agitation fluidized bed granulation, and effect of the damping speed on the granule properties of mass median diameter, geometric standard deviation, apparent density, yield, friability and specific surface area were investigated. Film coating by an aqueous acrylic copolymer (Eudragit NE-30D) was carried out using the core particles granulated under three levels of damping speeds, and the drug release properties of each coated product were identified. Relationship between properties of core particles and the drug release properties were clarified and the optimal granulation conditions to make optimal core particles for film coating were determined.

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