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Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers.

Authors
  • Arthanari, Saravanakumar1
  • Mani, Ganesh1
  • Jang, Jun Ho2
  • Choi, Je O2
  • Cho, Yun Ho2
  • Lee, Jung Ho3
  • Cha, Seung Eun4, 5
  • Oh, Han Seok1
  • Kwon, Deok Han2
  • Jang, Hyun Tae1, 4
  • 1 a Department of Chemical Engineering , Hanseo University , Chungcheongnam-Do , South Korea.
  • 2 c Seoryeong High School , Chungcheongnam-Do , South Korea.
  • 3 d Garak High School , Seoul , South Korea.
  • 4 b Hanseo Regional Innovation Center, Hanseo University , Chungcheongnam-Do , South Korea.
  • 5 e Department of Business Administration , Sungkyunkwan University , Seoul , South Korea.
Type
Published Article
Journal
Artificial Cells Nanomedicine and Biotechnology
Publisher
Informa UK (Taylor & Francis)
Publication Date
May 2016
Volume
44
Issue
3
Pages
847–852
Identifiers
DOI: 10.3109/21691401.2014.986676
PMID: 25510448
Source
Medline
Keywords
License
Unknown

Abstract

The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds. As much as 90% of the GH was released from the electrospun fibers within 6 h of incubation. Beyond this, the release was sustained for 24 h. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH-loaded sodium alginate/PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound-healing applications.

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