Affordable Access

Access to the full text

Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Authors
  • Zhang, Cheng1
  • Grossier, Romain1
  • Candoni, Nadine1
  • Veesler, Stéphane1
  • 1 CNRS, Aix-Marseille Université, CINaM (Centre Interdisciplinaire de Nanosciences de Marseille), Campus de Luminy, Case 913, Marseille Cedex 09, F-13288, France , Marseille Cedex 09 (France)
Type
Published Article
Journal
Biomaterials Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Nov 24, 2021
Volume
25
Issue
1
Identifiers
DOI: 10.1186/s40824-021-00243-5
Source
Springer Nature
Keywords
Disciplines
  • Review
License
Green

Abstract

This review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” and/or “off-chip”, depending on where cross-linkers are introduced. Various strategies are described and compared. Microparticle properties such as size, shape, concentration, stability and mechanical properties are discussed. Finally, we consider future perspectives for the preparation of hydrogel microparticles and their potential applications.

Report this publication

Statistics

Seen <100 times