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Prenylated Flavonoids from the Roots of Tephrosia rhodesica

Authors
  • Atilaw, Yoseph
  • Muiva-Mutisya, Lois
  • Bogaerts, Jonathan
  • Duffy, Sandra
  • Valkonen, Arto
  • Heydenreich, Matthias
  • Avery, Vicky M.
  • Rissanen, Kari
  • Erdélyi, Máté
  • Yenesew, Abiy
Publication Date
Jan 01, 2020
Identifiers
DOI: 10.1021/acs.jnatprod.0c00245
OAI: oai:DiVA.org:uu-421274
Source
DiVA - Academic Archive On-line
Keywords
Language
English
License
Green
External links

Abstract

Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 mu g and IC50 = 5-15 mu M) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.

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