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Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.

Authors
  • Miranda, C L
  • Aponso, G L
  • Stevens, J F
  • Deinzer, M L
  • Buhler, D R
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Feb 28, 2000
Volume
149
Issue
1-2
Pages
21–29
Identifiers
PMID: 10737704
Source
Medline
License
Unknown

Abstract

The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR.

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