Prenatal sonographic diagnosis of premature constriction of the fetal ductus arteriosus after maternal self-medication with benzydamine hydrochloride: report of 3 cases and review of the literature.
Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland.
Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland. [email protected]
- Published Article
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
- Publication Date
Mar 01, 2015
We report 3 cases of prenatal diagnosis of premature constriction of the ductus arteriosus after maternal benzydamine hydrochloride therapy (3-mg lozenges) in third-trimester pregnancies. In each case, fetal echocardiography revealed a dilated, hypocontractile right ventricle with severe tricuspid regurgitation and constriction of the ductus arteriosus. Although the effect of indomethacin and other nonsteroidal anti-inflammatory drugs on prenatal ductal constriction is well known, readily available over-the-counter nonsteroidal anti-inflammatory drugs such as benzydamine can have an equally deleterious effect and are best avoided in the third trimester of pregnancy.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/25715374