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Prenatal diagnosis from cystic hygroma fluid: the value of fluorescence in situ hybridization.

Authors
  • Donnenfeld, A E
  • Lockwood, D
  • Lamb, A N
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Publication Date
Oct 01, 2001
Volume
185
Issue
4
Pages
1004–1008
Identifiers
PMID: 11641692
Source
Medline
License
Unknown

Abstract

We conclude that the optimal approach for the prenatal diagnosis of chromosome abnormalities from cystic hygroma samples is to perform both traditional cytogenetic studies and interphase prenatal fluorescence in situ hybridization evaluation for the most common aneuploidies that involve chromosomes 13, 18, 21, X, and Y. With this combined approach, our data indicate that, in viable pregnancies with a fluid sample of >5 mL, a 90% diagnostic success rate can be achieved.

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