Prematurity and perinatal adversity effects hypothalamic-pituitary-adrenal axis reactivity to social evaluative threat in adulthood.
College of Nursing, University of Rhode Island, Kingston, Rhode Island.
The Sanford School of Social and Family Dynamics, Arizona State University, Tempe, Arizona.
Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, Irvine, California.
Johns Hopkins University School of Nursing, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University School of Medicine, Baltimore, Maryland.
- Published Article
Wiley (John Wiley & Sons)
- Publication Date
Dec 01, 2017
This study examined the long-term effects of prematurity and perinatal adversity on individual differences in stress-related reactivity and regulation of the HPA axis. A prospective sample of 155 infants born preterm and healthy (n = 20), medical illness (n = 48), neurological illness (n = 26), and small for gestational age (n = 24) and full-term (n = 37) were recruited between 1985 and 1989. At age 23 years, multiple saliva samples were collected before and after participation in the Trier Social Stress Test and later assayed for cortisol. Results reveal that at age 23 years, infants born premature with neurological complications showed higher cortisol reactivity to social evaluative threat compared to either their full-term, small for gestation age, medically ill, or healthy preterm peers. Findings are discussed in terms of implications for contemporary theories that propose effects of early adversity on biological sensitivities and susceptibilities, which translate experience into developmental outcomes related to poor health and risk for disease.
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This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/29080326