Affordable Access

Preliminary toxicity studies on ethanol extracts of the aerial parts of Artemisia abyssinica and A. Inculta in mice.

Authors
  • Qureshi, S
  • Ageel, A M
  • al-Yahya, M A
  • Tariq, M
  • Mossa, J S
  • Shah, A H
Type
Published Article
Journal
Journal of Ethnopharmacology
Publisher
Elsevier
Publication Date
Feb 01, 1990
Volume
28
Issue
2
Pages
157–162
Identifiers
PMID: 2329806
Source
Medline
License
Unknown

Abstract

Ethanolic extracts of the aerial parts of Artemisia abyssinica and A. inculta were subjected to acute toxicity observations in mice for 24 h and chronic toxicity evaluation for 3 months. External morphological changes, visceral toxicity, haematological changes, spermatogenic dysfunction and effect on body weight and vital organ weight were recorded. In both the chronically treated groups, no significant acute mortality was observed up to 3 g/kg p.o. There was no weight gain in A. abyssinica chronically-treated mice while the weight gain of A. inculta-treated animals matched that of the control group. Significant sperm damage was observed in A. abyssinica-treated mice while A. inculta failed to produce any significant spermatotoxic effect.

Report this publication

Statistics

Seen <100 times