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A preliminary study on the effects of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication.

Authors
  • Collins, P
  • Ford, I
  • Ball, D
  • Macaulay, E
  • Greaves, M
  • Brittenden, J
Type
Published Article
Journal
European Journal of Vascular and Endovascular Surgery
Publisher
Elsevier
Publication Date
Mar 01, 2006
Volume
31
Issue
3
Pages
266–273
Identifiers
PMID: 16360327
Source
Medline
License
Unknown

Abstract

This study is the first to show that platelet aggregation is reduced immediately following treadmill exercise to maximum walking distance in patients with IC despite a rise in sP-selectin and vWF, suggesting endothelial activation. The inhibition of platelet aggregation after exercise in subjects on antiplatelet and statin therapy suggests that exercise is unlikely to exacerbate platelet thrombus formation in patients with IC.

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